Dr. Peter Benton (ERIQ LA SALLE) treats a young homosexual in the final stages of AIDS. The man's mother decides to make her son comfortable but not to perform surgery on him that could sustain his life. Meanwhile, Dr. Mark Greene (ANTHONY EDWARDS) is sued for malpractice regarding the death of Jodi O'Brien (from "Love's Labor Lost" episode). Greene learns that Dr. Swift (MICHAEL IRONSIDE) and the hospital will support him in the suit, claiming he is not at fault. Swift finally offers Greene an attending job in the ER for the next year.

Dr. Susan Lewis (SHERRY STRINGFIELD) deals with her difficult sister, Chloe (KATHLEEN WILHOITE), who still lives with her. Chloe's baby complicates the situation.

On his last day in the ER, John Carter (NOAH WYLE) helps Dr. Douglas Ross (GEORGE CLOONEY) with a 12-year-old cancer patient who develops complications from chemotherapy. Carter must evaluate Dr. Peter Benton (ERIQ LA SALLE), his resident in the ER. After he gives Benton a low evaluation, he learns that Benton gave him an excellent evaluation. Benton offers Carter a sub-I internship in surgery since the original candidate refused the offer. Elated, Carter's confidence continues to grow as a doctor.

Finally, the ER group gathers at church for the wedding of Nurse Carol Hathaway (JULIANNA MARGULIES) and Dr. Taglieri (RICK ROSSOVICH). After learning that she doesn't love him as much as he loves her, Taglieri walks away from Hathaway. The ER group supports Hathaway and has a party anyway without the wedding.